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Accutane (Roaccatune; generic name Isotretinoin) by Roche is a powerful drug used for acne treatment. Accutane usage is 2 times a day. Four to five months of isotretinoin treatment usually leads to clearing of acne for one year or more after the medicine is stopped. Most other acne-controlling medicines are antibacterial agents, which are effective only if the medicine is used daily.